One-step selective synthesis of branched 1-O-alkyl-glycerol/diglycerol monoethers by catalytic reductive alkylation of ketones.

Yan Shi (1) , Wissam Dayoub (2) , Guo-Rong Chen (1) , Marc Lemaire (2)

1 East China University of Science and Technology
2 ICBMS - Institut de Chimie et Biochimie Moléculaires et Supramoléculaires

Branched 1-O-alkyl glycerol and diglycerol monoethers were obtained in good yields and high selectivity by a straightforward catalytic reductive alkylation of glycerol with relevant ketones in the presence of 0.5 mol% of Pd/C under 10 bar of hydrogen pressure using a Brønsted acid as the co-catalyst.

Domaines: Chimie organique

Yan Shi, Wissam Dayoub, Guo-Rong Chen, Marc Lemaire. One-step selective synthesis of branched 1-O-alkyl-glycerol/diglycerol monoethers by catalytic reductive alkylation of ketones.. Science China Chemistry, 2010, 53 (9), pp.1953-1956. ⟨hal-01166842⟩