Both hepatic and body iron stores are increased in dysmetabolic iron overload syndrome. A case-control study

Caroline Jezequel (1) , Fabrice Lainé (2, 3) , Bruno Laviolle (2, 4) , Anita Kiani (5) , Edouard Bardou-Jacquet (6, 3) , Yves Deugnier (6, 3)

1 Service des Maladies de l'Appareil Digestif [CHU Rennes]
2 CIC - Centre d'Investigation Clinique [Rennes]
3 Foie, métabolismes et cancer
4 Service de Pharmacologie [Rennes]
5 Département de Radiologie [CHU de Rennes]
6 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]

BACKGROUND & AIMS: Hepatic iron is increased in dysmetabolic iron overload syndrome (DIOS). Whether this reflects elevated body iron stores is still debated. The study was aimed at assessing body iron stores in DIOS patients by calculating the amount of mobilized iron (AMI). METHODS: We conducted a prospective case-control study comparing AMI in 12 DIOS patients and 12 overweight normoferritinemic subjects matched on BMI and age. All participants were phlebotomized until serum ferritin dropped ≤ 50μg/L. RESULTS: The two groups were comparable with respect to metabolic abnormalities and differed according to serum ferritin levels only. AMI was significantly (p\textless0.0001) higher in DIOS (2.5g±0.7) than in controls (0.8g±0.3). No side effects were related to phlebotomies

Domains: Life Sciences [q-bio]

Caroline Jezequel, Fabrice Lainé, Bruno Laviolle, Anita Kiani, Edouard Bardou-Jacquet, et al.. Both hepatic and body iron stores are increased in dysmetabolic iron overload syndrome. A case-control study. PLoS ONE, 2015, 10 (6), pp.e0128530. ⟨10.1371/journal.pone.0128530⟩. ⟨hal-01162388⟩