A gradient of sex linkage in the pseudoautosomal region of the human sex chromosomes.

François Rouyer (1) , Marie-Christine Simmler (1) , Christophe Johnsson (1) , Gilles Vergnaud (2, 3) , Howard J. Cooke (4, 1) , Jean Weissenbach (1)

1 Biologie moléculaire des infections virales et cancérologie [Paris]
2 IGM - Institut de génétique et microbiologie [Orsay]
3 ENSTA Paris - École Nationale Supérieure de Techniques Avancées
4 MRC Mammalian Genome Unit, King's Buildings

Three independent pseudoautosomal loci are linked to sex determination at frequencies which define a gradient of linkage. The segregation patterns of these loci indicate that X/Y recombination results from a single obligatory meiotic crossing-over in the pseudoautosomal region. Recombination in male germ cells in the terminal regions of the short arms of the X and Y chromosomes in 10-fold greater than between the same regions of the X chromosomes in female germ cells.

Domaines: Sciences du Vivant [q-bio]

François Rouyer, Marie-Christine Simmler, Christophe Johnsson, Gilles Vergnaud, Howard J. Cooke, et al.. A gradient of sex linkage in the pseudoautosomal region of the human sex chromosomes.. Nature, 1986, 319 (6051), pp.291-5. ⟨10.1038/319291a0⟩. ⟨hal-01160710⟩