Towards an HBV cure: state-of-the-art and unresolved questions-report of the ANRS workshop on HBV cure.

Mirjam B Zeisel (1) , Julie Lucifora (2) , William S Mason (3) , Camille Sureau (4) , Jürgen Beck (5) , Massimo Levrero (6) , Michael Kann (7) , Percy A Knolle (8) , Monsef Benkirane (9) , David Durantel (2) , Marie-Louise Michel (10) , Brigitte Autran (11, 12) , Cosset François-Loïc (13) , Hélène Strick-Marchand (14) , Christian Trépo (15, 2) , Jia-Horng Kao , Fabrice Carrat (16, 17) , Karine Lacombe (17, 16, 18) , Raymond F Schinazi (19) , Françoise Barré-Sinoussi (20) , Jean-François Delfraissy (21) , Fabien Zoulim (2, 15)

1 Maladies Virales et Hépatiques
2 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon
3 Fox Chase Cancer Center
4 INTS - Institut National de la Transfusion Sanguine [Paris]
5 University Hospital Freiburg
6 UNIROMA - Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome]
7 MFP - Microbiologie Fondamentale et Pathogénicité
8 TUM - Technische Universität Munchen - Technical University Munich - Université Technique de Munich
9 IGH - Institut de génétique humaine
10 PVHB - Pathogenèse des Virus de l'Hépatite B
11 CIMI - Centre d'Immunologie et de Maladies Infectieuses
12 CHU Pitié-Salpêtrière [AP-HP]
13 CIRI - Centre International de Recherche en Infectiologie
14 Immunité Innée - Innate Immunity
15 HCL - Hospices Civils de Lyon
16 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
17 SU - Sorbonne Université
18 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
19 Emory University [Atlanta, GA]
20 Régulation des Infections Rétrovirales
21 France REcherche Nord & sud Sida-hiv Hépatites (FRENSH)

HBV infection is a major cause of liver cirrhosis and hepatocellular carcinoma. Although HBV infection can be efficiently prevented by vaccination, and treatments are available, to date there is no reliable cure for the >240 million individuals that are chronically infected worldwide. Current treatments can only achieve viral suppression, and lifelong therapy is needed in the majority of infected persons. In the framework of the French National Agency for Research on AIDS and Viral Hepatitis 'HBV Cure' programme, a scientific workshop was held in Paris in June 2014 to define the state-of-the-art and unanswered questions regarding HBV pathobiology, and to develop a concerted strategy towards an HBV cure. This review summarises our current understanding of HBV host-interactions leading to viral persistence, as well as the roadblocks to be overcome to ultimately address unmet medical needs in the treatment of chronic HBV infection.

Domaines: Sciences du Vivant [q-bio]

Mirjam B Zeisel, Julie Lucifora, William S Mason, Camille Sureau, Jürgen Beck, et al.. Towards an HBV cure: state-of-the-art and unresolved questions-report of the ANRS workshop on HBV cure.. Gut, 2015, 64 (8), pp.1314-26. ⟨10.1136/gutjnl-2014-308943⟩. ⟨hal-01157784⟩