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In vivo evaluation of paclitaxel-loaded lipid nanocapsules after intravenous and oral administration on resistant tumor.

Abstract :

UNLABELLED: Aim & methods: The aim of the present work was to encapsulate paclitaxel (Ptx) in various lipid nanocapsules (LNCs) formulations and then to compare their pharmacokinetics and efficacy on a subcutaneous isograft model in rats.

RESULTS: Three different Ptx formulations were obtained. Drug payloads ranged from 1.32 to 3.62 mg Ptx/g of formulation. After oral administration the area under concentration-time curve was higher (p < 0.05) if Ptx was encapsulated, (1,2 Distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(PEG)] (DSPE-PEG-NH2)) LNCs displaying the highest area under concentration-time curve (p < 0.05). Efficacy was better than control for standard LNCs after oral administration (p < 0.05) and for (DSPE-PEG-NH2) LNCs after intravenous administration. Despite good absorption, (DSPE-PEG-NH2) LNCs failed to remain efficient after oral route.

CONCLUSION: This study highlights the importance of efficacy studies paired to pharmacokinetic studies for nanomedicines.

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Journal articles
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https://hal.archives-ouvertes.fr/hal-01153494
Contributor : Okina Université d'Angers <>
Submitted on : Tuesday, May 19, 2015 - 6:38:26 PM
Last modification on : Sunday, May 24, 2020 - 2:18:04 AM

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Anne-Claire Groo, M Bossière, L Trichard, Pierre Legras, Jean-Pierre Benoît, et al.. In vivo evaluation of paclitaxel-loaded lipid nanocapsules after intravenous and oral administration on resistant tumor.. Nanomedicine, Future Medicine, 2015, 10 (4), pp.589-601. ⟨10.2217/nnm.14.124⟩. ⟨hal-01153494⟩

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