Hippocampal GABAergic neurons are susceptible to amyloid-beta toxicity in vitro and are decreased in number in the Alzheimer's disease TgCRND8 mouse model

S. Krantic (1, 2, 3) , N. Isorce (3) , N. Mechawar (3) , M.A. Davoli (3) , E. Vignault (3) , M. Albuquerque (3) , J.G. Chabot (3) , Emmanuel Moyse (4, 5) , J.P. Chauvin (6) , I. Aubert (7, 8) , J. Mclaurin (8, 9) , R. Quirion (3)

1 INMED - INSERM U901 - Institut de Neurobiologie de la Méditerranée [Aix-Marseille Université]
2 INSERM - Institut National de la Santé et de la Recherche Médicale
3 Department of Psychiatry [Montréal]
4 PRC - Physiologie de la reproduction et des comportements [Nouzilly]
5 Physiologie Neurovégétative
6 IBDM - Institut de Biologie du Développement de Marseille
7 Sunnybrook Health Sciences Center
8 Faculty of Medicine
9 Tanz Center Research in Neurodegenerative Diseases [Toronto]

absent

Mots clés: alzheimer's disease; amyloid beta protein; gabaergic neuron; hippocampus; tgcrnd8 mice; neuronal cell death; neuroscience; hippocampe; primary cell culture

Domaines: Sciences du Vivant [q-bio]

S. Krantic, N. Isorce, N. Mechawar, M.A. Davoli, E. Vignault, et al.. Hippocampal GABAergic neurons are susceptible to amyloid-beta toxicity in vitro and are decreased in number in the Alzheimer's disease TgCRND8 mouse model. Journal of Alzheimer's Disease, 2012, 29 (2), pp.293-308. ⟨10.3233/JAD-2011-110830⟩. ⟨hal-01129610⟩