A Multi-Atlas Based Method for Automated Anatomical Rat Brain MRI Segmentation and Extraction of PET Activity

Sophie Lancelot (1, 2) , Roxane Roche (3) , Afifa Slimen (3) , Caroline Bouillot (3) , Elise Levigoureux (1, 2) , Jean-Baptiste Langlois (3) , Luc Zimmer (1, 3, 2) , Nicolas Costes (3)

1 BIORAN - Radiopharmaceutical and Neurochemical Biomarkers
2 HCL - Hospices Civils de Lyon
3 CERMEP - imagerie du vivant - Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant

Preclinical in vivo imaging requires precise and reproducible delineation of brain structures. Manual segmentation is time consuming and operator dependent. Automated segmentation as usually performed via single atlas registration fails to account for anatomo-physiological variability. We present, evaluate, and make available a multi-atlas approach for automatically segmenting rat brain MRI and extracting PET activies.

Domaines: Imagerie; Neurosciences [q-bio.NC]

Sophie Lancelot, Roxane Roche, Afifa Slimen, Caroline Bouillot, Elise Levigoureux, et al.. A Multi-Atlas Based Method for Automated Anatomical Rat Brain MRI Segmentation and Extraction of PET Activity. PLoS ONE, 2014, 9 (10), pp.0109113. ⟨10.1371/journal.pone.0109113⟩. ⟨hal-01128452⟩