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A Sensitive Zinc-Activated 129Xe MRI Probe

Abstract : Xenon capsule: A smart 129Xe NMR-based sensor of Zn2+ ions for magnetic resonance imaging (MRI) is proposed. The resonance frequency of xenon encapsulated in a cryptophane that bears a nitrilotriacetic ligand moiety varies when Zn2+ ions are present in solution (see picture). With hyper-polarized gas, such a construct enables detection of 100 nM zinc in one xenon batch, a threshold 300 times lower than achieved with gadolinium chelates.
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Submitted on : Monday, February 16, 2015 - 2:46:38 PM
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Naoko Kotera, Nawal Tassali, Estelle Léonce, Céline Boutin, Patrick Berthault, et al.. A Sensitive Zinc-Activated 129Xe MRI Probe. Angewandte Chemie International Edition, 2012, 51 (17), pp.4100-4103. ⟨10.1002/anie.201109194⟩. ⟨hal-01117150⟩



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