Skip to Main content Skip to Navigation
Journal articles

Effect of pH and Counterions on the Encapsulation Properties of Xenon in Water-Soluble Cryptophanes

Abstract : In the 129Xe NMR-based biosensing approach in which the hyperpolarized noble gas is transported to biological receptors for a sensitive molecular imaging, cryptophanes are excellent xenon host systems. However to avoid formation of self-organized systems, these hydrophobic cage molecules can be rendered water soluble by introduction of ionic groups. We show that the sensitivity of xenon to its local environment and the presence of these ionic functions can lead to interesting properties. For a first water-soluble cryptophane derivative, we show that a precise monitoring of the local pH can be performed. For a second cryptophane, the presence of ionic groups close to the cryptophane cavity modifies the xenon binding constant and in–out exchange rate. The latter allows the tuning of physical properties of xenon–cryptophane interactions without resorting to a change of the cavity size. These results open new perspectives on the influence of chemical modifications of cryptophanes for optimizing the biosensor properties.
Document type :
Journal articles
Complete list of metadatas

https://hal.archives-ouvertes.fr/hal-01116898
Contributor : Pourlc Déposant <>
Submitted on : Sunday, February 15, 2015 - 9:30:24 PM
Last modification on : Friday, September 11, 2020 - 3:01:23 AM

Links full text

Identifiers

Citation

Patrick Berthault, Hervé Desvaux, Thierry Wendlinger, Marina Gyejacquot, Antoine Stopin, et al.. Effect of pH and Counterions on the Encapsulation Properties of Xenon in Water-Soluble Cryptophanes. Chemistry - A European Journal, Wiley-VCH Verlag, 2010, 16 (43), pp.12941-12946. ⟨10.1002/chem.201001170⟩. ⟨hal-01116898⟩

Share

Metrics

Record views

232