How nanoparticles can solve resistance and limitation in PDT efficiency
Résumé
PDT efficiency photosensitizers can be improved by different ways:
development of targeted photosensitizers that also present rapid clearance from
normal tissues, photosensitizers that own better photophysical properties (such as
absorption in the red to use light that can better penetrate tissue, limited photobleaching),
photosensitizers whose pharmacokinetics matched to the application,
improve light equipments and the selective delivery of the activating light. In this
chapter, our aim is to address how nanoparticles could be one of the solutions to
improve PDT efficiency and to bypass the phenomena of resistance and limitations
to PDT. We will describe how the use of nanoparticles can be positive for activation
system, biodistribution properties, tumor selectivity by selecting judicious molecular
and cellular targets.