Application of Cooperative Iron/Copper Catalysis to a Palladium-Free Borylation of Aryl Bromides with Pinacolborane

Flavien Labre (1) , Pierre Y. Chavant (1) , Elisabet Duñach (2) , Sandra Olivero (2) , Pierre Bannwarth (2)

1 DCM - SeRCO - Département de Chimie Moléculaire - Synthèse Et Réactivité en Chimie Organique
2 LCMBA - Laboratoire de Chimie des Molécules Bioactives et des Arômes

A new cooperative copper/iron catalysis for the borylation of various aryl bromides with pinacolborane, at −10 °C, is reported. Use of the toxic, precious metal Pd is avoided. The mechanism of the protodebromination side reaction is discussed.

Domaines: Chimie organique; Catalyse

Flavien Labre, Pierre Y. Chavant, Elisabet Duñach, Sandra Olivero, Pierre Bannwarth. Application of Cooperative Iron/Copper Catalysis to a Palladium-Free Borylation of Aryl Bromides with Pinacolborane. Organic Letters, 2014, 16 (9), pp.2366. ⟨10.1021/ol500675q⟩. ⟨hal-01080404⟩