Systemic approach for toxicity analysis

Abstract : A high-level Petri net framework is introduced for the toxic risk assessment in biological and bio-synthetic systems. Unlike empirical techniques mostly used in toxicology or toxicogenomics, we propose a systemic approach consisting of a series of behavioral rules (reactions) that depend on abstract discrete "expression" levels of involved agents (species). We introduce a finite state high-level Petri net model allowing exhaustive verification (model-checking) of properties related to equilibrium alteration or appearing of hazardous behaviors. The approach is applied to the study of the impact of the aspartame assimilation into the blood glucose regulation process.
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Contributor : Frédéric Davesne <>
Submitted on : Wednesday, October 29, 2014 - 1:05:46 PM
Last modification on : Monday, October 28, 2019 - 11:00:24 AM

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  • HAL Id : hal-01078546, version 1

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Cinzia Di Giusto, Hanna Klaudel, Franck Delaplace. Systemic approach for toxicity analysis. 5th International Workshop on Biological Processes and Petri Nets (BioPPN 2014), Jun 2014, Tunis, Tunisia. pp.30--44. ⟨hal-01078546⟩

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