Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation

Pietro Mesirca (1) , J. Alig (2) , Angelo Torrente (1) , J.C Muller (3) , L. Marger (1) , A. Rollin (1) , C. Marquilly (1) , Anne Vincent (1) , Stefan Dübel (1) , Isabelle Bidaud (1) , Anne Fernandez (4) , A. Seniuk (5) , B. Engeland (2) , J. Singh (6) , L. Miquerol (7) , H. Ehmke (3) , T. Eschenhagen (8) , Joël Nargeot (1) , K. Wickman (9) , D. Isbrandt (2) , Matteo E. Mangoni (1)

1 IGF - Institut de Génomique Fonctionnelle
2 Experimental Neuropediatrics
3 Department of Cellular and Integrative Physiology
4 IGH - Institut de génétique humaine
5 Center for Experimental Medicine
6 Department of Experimental Pharmacology and Toxicology
7 IBDM - Institut de Biologie du Développement de Marseille
8 CVRC - Cardiovascular Research Center Hamburg
9 Department of Pharmacology

Domaines: Génétique

Pietro Mesirca, J. Alig, Angelo Torrente, J.C Muller, L. Marger, et al.. Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation. Nature Communications, 2014, 5, pp.4664. ⟨10.1038/ncomms5664⟩. ⟨hal-01059204⟩