Plasma jet-induced tissue oxygenation: potentialities for new therapeutic strategies

Abstract : The lack of oxygen is a major reason for the resistance of tumor cells to treatments such as radiotherapies. A large number of recent publications on non-thermal plasma applications in medicine report cell behavior modifications and modulation of soluble factors. This in vivo study tested whether such modifications can lead to vascular changes in response to plasma application. Two in situ optical-based methods were used simultaneously, in real time, to assess the effect of non-thermal plasma on tissue vasculature. Tissue oxygen partial pressure (pO2) was measured using a time-resolved luminescence-based optical probe, and the microvascular erythrocyte flow was determined by laser Doppler flowmetry. When plasma treatment was applied on mouse skin, a rapid pO2 increase (up to 4 times) was subcutaneously measured and correlated with blood flow improvement. Such short duration, i.e. 5 min, plasma-induced effects were shown to be locally restricted to the treated area and lasted over 120 min. Further investigations should elucidate the molecular mechanisms of these processes. However, improvement of oxygenation and perfusion open new opportunities for tumor treatments in combination with radiotherapy, and for tumor blood vessel normalization based strategies.
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Journal articles
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https://hal.archives-ouvertes.fr/hal-01052552
Contributor : Eric Robert <>
Submitted on : Monday, July 28, 2014 - 10:01:50 AM
Last modification on : Friday, April 26, 2019 - 9:06:02 AM

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Collet G, Eric Robert, Alice Lenoir, Marc Vandamme, Thibault Darny, et al.. Plasma jet-induced tissue oxygenation: potentialities for new therapeutic strategies. Plasma Sources Science and Technology, IOP Publishing, 2014, pp.Plasma Sources Sci. Technol. 23 (2014) 012005. ⟨10.1088/0963-0252/23/1/012005⟩. ⟨hal-01052552⟩

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