Biodistribution of ultrasmall gadolinium-based nanoparticles as theranostic agent : Application to brain tumors

I. Miladi (1) , G. Le Duc (2) , D. Kryza (3) , A. Berniard (1) , P. Mowat (1) , S. Roux (4) , J. Taleb (1) , P. Bonazza (1) , P. Perriat (5) , F. Lux (1) , O. Tillement (1) , C. Billotey (3) , M. Janier (3)

1 LPCML - Laboratoire de Physico-Chimie des Matériaux Luminescents
2 ESRF - European Synchrotron Radiation Facility
3 Service de médecine nucléaire
4 UTINAM - Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213)
5 MATEIS - Matériaux, ingénierie et science [Villeurbanne]

Gadolinium-based nanoparticles are novel objects with interesting physical properties, allowing their use for diagnostic and therapeutic applications. Gadolinium-based nanoparticles were imaged following intravenous injection in healthy rats and rats grafted with 9L gliosarcoma tumors using magnetic resonance imaging and scintigraphic imaging. Quantitative biodistribution using gamma-counting of each sampled organ confirmed that these nanoparticles were rapidly cleared essentially by renal excretion. Accumulation of these nanoparticles in 9L gliosarcoma tumors implanted in the rat brain was quantitated. This passive and long-duration accumulation of gadolinium-based nanoparticles in tumor, which is related to disruption of the blood–brain barrier, is in good agreement with the use of these nanoparticles as radiosensitizers for brain tumors.

Mots clés: Gadolinium-based nanoparticles; brain tumour; biodistribution

Domaines: Cancer; Chimie thérapeutique; Imagerie

I. Miladi, G. Le Duc, D. Kryza, A. Berniard, P. Mowat, et al.. Biodistribution of ultrasmall gadolinium-based nanoparticles as theranostic agent : Application to brain tumors. Journal of Biomaterials Applications, 2012, 28 (385-394), pp.IF 2.6. ⟨10.1177/0885328212454315⟩. ⟨hal-00796693⟩