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Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism

Joerg Martin Buescher 1 Wolfram Liebermeister 2 Matthieu Jules 3 Markus Uhr 4 Jan Muntel 5 Eric Botella 6 Bernd Hessling 5 Roelco Jacobus Kleijn 1 Ludovic Le Chat 3 François Lecointe 3 Ulrike Mäder 5 Pierre Nicolas 7 Sjouke Piersma 8 Frank Rügheimer 9 Dorte Becher 5 Philippe Bessières 7 Elena Bidnenko 3 Emma Denham 8 Etienne Dervyn 3 Kevin Devine 6 Geoff Doherty 10 Samuel Drulhe 9 Liza Felicori 11 Mark Fogg 12 Anne Goelzer 7 Annette Hansen 6 Colin Harwood 13 Michael Hecker 5 Sebastian Hubner 14 Claus Hultschig 15 Hanne Jarmer 16 Edda Klipp 2 Aurelie Leduc 7 Peter Lewis 10 Frank Molina 11 Philippe Noirot 3 Sabine Peres 11 Nathalie Pigeonneau 3 Susanne Pohl 17 Simon Rasmussen 16 Bernd Rinn 15 Marc Schaffer 5 Julian Schnidder 18 Benno Schwikowski 9 Jan Maarten van Dijl 8 Patrick Veiga 7 Sean Walsh 19 Anthony Wilkinson 12 Jörg Stelling 4 Stephane Aymerich 3 Uwe Sauer 1
Abstract : Adaptation of cells to environmental changes requires dynamic interactions between metabolic and regulatory networks, but studies typically address only one or a few layers of regulation. For nutritional shifts between two preferred carbon sources of Bacillus subtilis, we combined statistical and model-based data analyses of dynamic transcript, protein, and metabolite abundances and promoter activities. Adaptation to malate was rapid and primarily controlled posttranscriptionally compared with the slow, mainly transcriptionally controlled adaptation to glucose that entailed nearly half of the known transcription regulation network. Interactions across multiple levels of regulation were involved in adaptive changes that could also be achieved by controlling single genes. Our analysis suggests that global trade-offs and evolutionary constraints provide incentives to favor complex control programs.
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Joerg Martin Buescher, Wolfram Liebermeister, Matthieu Jules, Markus Uhr, Jan Muntel, et al.. Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism. Science, American Association for the Advancement of Science, 2012, 335 (6072), pp.1099-1103. ⟨10.1126/science.1206871⟩. ⟨hal-01000240⟩



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