Concise synthesis of an enantiopure bicyclic pyrazinone as constrained peptidomimetic building block.
Résumé
A concise synthetic route has been developed for the preparation of a constrained peptidomimetic pyrazinone building block. From hydroxy-L-lysine, the desired pyrazinone is obtained in 43% overall yield (6 steps) via an efficient deprotection-double cyclization sequence.