First substoichiometric version of the catalytic enantioselective addition of an alkyllithium to an aldehyde.

Baptiste Lecachey , Catherine Fressigné , Hassan Oulyadi (1) , Anne Harrison-Marchand , Jacques Maddaluno (1)

1 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse

A substoichiometric enantioselective version of the extremely fast nucleophilic addition of Alk-Li to RCHO is made possible thanks to a thorough analysis of the aggregation phenomena involved in the reaction: calculated quantities of LiCl must be added to the medium at the right time to keep the catalytic cycle running.

Domaines: Chimie organique

Baptiste Lecachey, Catherine Fressigné, Hassan Oulyadi, Anne Harrison-Marchand, Jacques Maddaluno. First substoichiometric version of the catalytic enantioselective addition of an alkyllithium to an aldehyde.. Chemical Communications, 2011, 47 (35), pp.9915-9917. ⟨10.1039/c1cc13513a⟩. ⟨hal-00991609⟩