Investigation on the properties of linear PLA-poloxamer and star PLA-poloxamine copolymers for temporary biomedical applications.

Adrien Leroy (1, 2, 3) , Coline Pinese (1) , Claire Bony (3, 2) , Xavier Garric (1) , Danièle Noël (3, 2) , Benjamin Nottelet (1) , Jean Coudane (1)

1 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]
2 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
3 Cellules souches mésenchymateuses, environnement articulaire et immunothérapies de la polyarthrite rhumatoide

The objective of this work was to develop and study newbiodegradable thermoplastics with improvedmechanical properties for potential use as temporary implantable biomaterials. Linear poloxamer and star-shaped poloxamine have been used as macroinitiators for the ring-opening polymerization (ROP) of lactide to yield high molecular weight PLA-based thermoplastic block copolymers. The influence of the nature of the macroinitiator, PLA crystallinity and initial molecular weight on the copolymers properties was investigated by performing a 7-week degradation test in PBS. The evaluation of water uptakes and molecular weights during the degradation pointed out an early hydrolytic degradation of the 100-kg∙mol−1 copolymers compared to the 200-kg∙mol−1 ones (molecular weight decrease of ca. 40% and 20%, respectively). A dramatic loss of tensile mechanical properties was also observed for the 100-kg∙mol−1 copolymers, whereas the 200-kg∙mol−1 copolymers showed stable or even slightly improved properties with Young's moduli around 500 MPa and yield strains around 3% to 4%. Finally, the cytocompatibility of the more stable 200 kg∙mol−1 copolymers was confirmed by murine mesenchymal stem cells (MSCs) culture.

Mots clés: Poly(lactide); Poloxamer; Poloxamine; Degradation properties; Mesenchymal stem cells; Cytocompatibility

Domaines: Chimie organique

Adrien Leroy, Coline Pinese, Claire Bony, Xavier Garric, Danièle Noël, et al.. Investigation on the properties of linear PLA-poloxamer and star PLA-poloxamine copolymers for temporary biomedical applications.. Materials Science and Engineering: C, 2013, 33 (7), pp.4133-4139. ⟨10.1016/j.msec.2013.06.001⟩. ⟨hal-00967461⟩