NMR methods for fragment selection

Isabelle Krimm (1)

1 Criblage de fragment

Fragment screening resides in the identification of minimal motifs responsible for the specific protein-ligand recognition. Once fragment hits have been identified, one needs to ensure that the fragments exhibit a specific binding mode. We will see how NMR can be used, if crystallographic resolution of protein-fragment complexes fails. In addition, we will see how to assess whether the protein undergoes conformational changes upon fragment binding

Domaines: Chimie analytique

Isabelle Krimm. NMR methods for fragment selection. Drug Discovery Chemistry 2014, Apr 2014, San Diego, United States. ⟨hal-00955933⟩