A DMAP-catalyzed mild and efficient synthesis of 1,2-dihydroquinazolines via a one-pot three-component protocol

Chamseddine Derabli (1) , Raouf Boulcina (1) , Gilbert Kirsch (2) , Bertrand Carboni (3) , Abdelmadjid Debache (1)

1 Laboratoire de Synthèse des Molécules d'intérêts Biologiques
2 SRSMC - Structure et Réactivité des Systèmes Moléculaires Complexes
3 ISCR - Institut des Sciences Chimiques de Rennes

An efficient and simple method for the synthesis of 1,2-dihydroquinazolines catalyzed by 4-(N,N-dimethylamino) pyridine (DMAP) from readily available aromatic or heteroaromatic aldehydes, 2-aminobenzophenone, and ammonium acetate under mild conditions is described. The scope and limitations of the method are discussed.

Keywords: Multicomponent reaction 1; 2-Dihydroquinazolines DMAP 2-Aminobenzophenone

Domains: Organic chemistry

Chamseddine Derabli, Raouf Boulcina, Gilbert Kirsch, Bertrand Carboni, Abdelmadjid Debache. A DMAP-catalyzed mild and efficient synthesis of 1,2-dihydroquinazolines via a one-pot three-component protocol. Tetrahedron Letters, 2014, 55 (1), pp.200-204. ⟨10.1016/j.tetlet.2013.10.157⟩. ⟨hal-00955594⟩