Batch emulsion polymerization mediated by poly(methacrylic acid) macroRAFT agents: one-pot synthesis of self-stabilized particles

Isabelle Chaduc (1) , Marion Girod (2) , Rodolphe Antoine (3) , Bernadette Charleux (1) , Franck d'Agosto (1) , Muriel Lansalot (1)

1 C2P2 - Laboratoire de Chimie, Catalyse, Polymères et Procédés, R 5265
2 ANABIO - ANAlyse BIOmoléculaire RMN et spectrométrie de masse (2011-2013)
3 LASIM - Laboratoire de Spectrométrie Ionique et Moléculaire

The present paper describes the successful one-pot synthesis of self-stabilized particles composed of amphiphilic block copolymers based on poly(methacrylic acid) (PMAA) obtained by polymerization-induced self-assembly. First, controlled radical polymerization of MAA is performed in water using the RAFT process by taking advantage of our recent results showing the successful RAFT polymerization of MAA in water [Chaduc Macromolecules 2012, 45, 1241−1247]. The so-formed hydrophilic macroRAFT agents are then chain-extended in situ with a hydrophobic monomer to form amphiphilic block copolymer chains of controlled molar mass that self-assemble into stable nanoparticles. Various parameters such as the pH, the molar mass and the concentration of the PMAA segments or the nature of the hydrophobic block have been investigated.

Domaines: Chimie analytique

Isabelle Chaduc, Marion Girod, Rodolphe Antoine, Bernadette Charleux, Franck d'Agosto, et al.. Batch emulsion polymerization mediated by poly(methacrylic acid) macroRAFT agents: one-pot synthesis of self-stabilized particles. Macromolecules, 2012, 45 (15), pp.5881-5893. ⟨10.1021/ma300875y⟩. ⟨hal-00955084⟩