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Evolutionary conservation of early mesoderm specification by mechanotransduction in Bilateria.

Thibaut Brunet 1 Adrien Bouclet 1 Padra Ahmadi 1 Démosthène Mitrossilis 1 Benjamin Driquez 1 Anne-Christine Brunet 1 Laurent Henry 1 Fanny Serman 1 Gaëlle Béalle 2 Christine Ménager 2 Frédéric Dumas-Bouchiat 3 Dominique Givord 3 Constantin Yanicostas 4 Damien Le Roy 3 Nora M. Dempsey 3 Anne Plessis 5 Emmanuel Farge 1
1 Mechanics and Genetics of Embryonic Development Group, PSL Research University
2 PECSA - Physicochimie des Electrolytes, Colloïdes et Sciences Analytiques
3 MNM - Micro et NanoMagnétisme
NEEL - Institut Néel
4 Zebrafish Models of Neurodegenerative Disorders
5 IJM (UMR_7592) - Institut Jacques Monod
Abstract : The modulation of developmental biochemical pathways by mechanical cues is an emerging feature of animal development, but its evolutionary origins have not been explored. Here we show that a common mechanosensitive pathway involving β-catenin specifies early mesodermal identity at gastrulation in zebrafish and Drosophila. Mechanical strains developed by zebrafish epiboly and Drosophila mesoderm invagination trigger the phosphorylation of β-catenin-tyrosine-667. This leads to the release of β-catenin into the cytoplasm and nucleus, where it triggers and maintains, respectively, the expression of zebrafish brachyury orthologue notail and of Drosophila Twist, both crucial transcription factors for early mesoderm identity. The role of the β-catenin mechanosensitive pathway in mesoderm identity has been conserved over the large evolutionary distance separating zebrafish and Drosophila. This suggests mesoderm mechanical induction dating back to at least the last bilaterian common ancestor more than 570 million years ago, the period during which mesoderm is thought to have emerged.
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https://hal.archives-ouvertes.fr/hal-00951438
Contributeur : Martine Bondidier <>
Soumis le : lundi 24 février 2014 - 17:03:10
Dernière modification le : mercredi 6 mai 2020 - 10:04:13

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UNIV-PARIS7 | ESPCI | PARISTECH | CNRS | IJM | CURIE | FNCLCC | PCC_UMR168 | UPMC | NEEL | UGA | INC-CNRS | PSL | USPC | SORBONNE-UNIVERSITE | SU-SCIENCES | UP-SCIENCES

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Thibaut Brunet, Adrien Bouclet, Padra Ahmadi, Démosthène Mitrossilis, Benjamin Driquez, et al.. Evolutionary conservation of early mesoderm specification by mechanotransduction in Bilateria.. Nature Communications, Nature Publishing Group, 2013, 4, pp.2821. ⟨10.1038/ncomms3821⟩. ⟨hal-00951438⟩

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