Bicyclic and tetracyclic diterpenes from a Trichoderma symbiont of Taxus baccata.

Emilie Adelin (1) , Claudine Servy (1) , Marie-Thérèse Martin (1) , Guillaume Arcile (1) , Bogdan I Iorga (1) , Pascal Retailleau (1) , Mercedes Bonfill , Jamal Ouazzani (1)

1 ICSN - Institut de Chimie des Substances Naturelles

Trichoderma atroviridae UB-LMA is an endophytic fungus isolated from Taxus baccata trees. Liquid-state fermentation coupled to in situ solid phase extraction (SPE) was applied, and four compounds were discovered. Compounds 2-4 belong to the harziane tetracyclic diterpene family. Bicylic compound 1 may represent the biosynthetic precursor of this scarce family of compounds.

Domaines: Chimie organique

Emilie Adelin, Claudine Servy, Marie-Thérèse Martin, Guillaume Arcile, Bogdan I Iorga, et al.. Bicyclic and tetracyclic diterpenes from a Trichoderma symbiont of Taxus baccata.. Phytochemistry, 2014, 97, pp.55-61. ⟨10.1016/j.phytochem.2013.10.016⟩. ⟨hal-00945561⟩