Encapsulation of complementary model drugs in spray-dried nanostructured materials

Abstract : Two model drugs of different physico-chemical and pharmaceutical properties (ibuprofen, acetaminophen) have been incorporated together or separately in silicabased microspheres using sol-gel and spray-drying processes. A variable amount of a neutral surfactant Brij-56 has also been added. The properties of the microspheres vary significantly depending on their composition. Three kinds of texture are identified: (1) silica containing spheroid nano-domains (formed by ibuprofen; diameters between 20 and 100 nm), (2) silica containing worm-like mesophases (formed by Brij-56 and both model drugs, typical correlation distances *6 nm), (3) silica intimately mixed with the drug (acetaminophen) without visible phase-separation. The kinetics of drug release in simulated intestinal fluid strongly depend on these textures. The association of ibuprofen and acetaminophen in a single type of microsphere and without surfactant favours a concomitant release. Possible mechanisms of materials' formation are discussed.
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Journal articles
Journal of Sol-Gel Science and Technology, Springer Verlag (Germany), 2013, 68 (2), pp.307-316. <10.1007/s10971-013-3170-y>


https://hal.archives-ouvertes.fr/hal-00921864
Contributor : Francesco Di Renzo <>
Submitted on : Sunday, December 22, 2013 - 10:16:03 AM
Last modification on : Sunday, December 22, 2013 - 10:16:03 AM

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Mohamed Fatnassi, Corine Tourné-Péteilh, Pradial Peralta, Thomas Cacciaguerra, Philippe Dieudonné, et al.. Encapsulation of complementary model drugs in spray-dried nanostructured materials. Journal of Sol-Gel Science and Technology, Springer Verlag (Germany), 2013, 68 (2), pp.307-316. <10.1007/s10971-013-3170-y>. <hal-00921864>

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