How Do Gangliosides Regulate RTKs Signaling?

Sylvain Julien (1, 2) , Marie Bobowski (1, 2) , Agata Steenackers (1, 2) , Xuefen Le Bourhis (2, 3) , Philippe Delannoy (1, 2)

1 UGSF - Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576
2 Université Lille Nord de France (COMUE)
3 Signalisation des facteurs de croissance dans le cancer du sein. Protéomique fonctionnelle

Gangliosides, the glycosphingolipids carrying one or several sialic acid residues, are located on the outer leaflet of the plasma membrane in glycolipid-enriched microdomains, where they interact with molecules of signal transduction pathways including receptors tyrosine kinases (RTKs). The role of gangliosides in the regulation of signal transduction has been reported in many cases and in a large number of cell types. In this review, we summarize the current knowledge on the biosynthesis of gangliosides and the mechanism by which they regulate RTKs signaling.

Mots clés: receptor tyrosine kinase; gangliosides; glycosylation; cell signaling; glycolpid-enriched microdomains

Domaines: Biochimie, Biologie Moléculaire

Sylvain Julien, Marie Bobowski, Agata Steenackers, Xuefen Le Bourhis, Philippe Delannoy. How Do Gangliosides Regulate RTKs Signaling?. Cells, 2013, 2, pp.751-767. ⟨10.3390/cells2040751⟩. ⟨hal-00916107⟩