Standardized evaluation framework for evaluating coronary artery stenosis detection, stenosis quantification and lumen segmentation algorithms in computed tomography angiography.

H. A. Kirişli 1, * M. Schaap 1 C. T. Metz 1 A. S. Dharampal 2 W. B. Meijboom 2 S. L. Papadopoulou 2 A. Dedic 3 K. Nieman 3, 4 M. A. De Graaf 2 M. F. L. Meijs 5 M. J. Cramer 5 A. Broersen 6 S. Cetin 7 A. Eslami 8 L. Flórez-Valencia 9 K. L. Lor 10 B. Matuszewski 11 I. Melki 12 B. Mohr 13 I. Oksüz 14 R. Shahzad 1 Chen Wang 15 P. H. Kitslaar 6 G. Unal 7 A. Katouzian 16 M. Orkisz 17 C. M. Chen 18 Frédéric Precioso 19 Laurent Najman 20 S. Masood 13 D. Unay 21 L. Van Vliet 22 R. Moreno 15 R. Goldenberg 23 E. Vuçini 24 G. P. Krestin 4 W. J. Niessen 1 T. Van Walsum 1
Abstract : Though conventional coronary angiography (CCA) has been the standard of reference for diagnosing coronary artery disease in the past decades, computed tomography angiography (CTA) has rapidly emerged, and is nowadays widely used in clinical practice. Here, we introduce a standardized evaluation framework to reliably evaluate and compare the performance of the algorithms devised to detect and quantify the coronary artery stenoses, and to segment the coronary artery lumen in CTA data. The objective of this evaluation framework is to demonstrate the feasibility of dedicated algorithms to: (1) (semi-)automatically detect and quantify stenosis on CTA, in comparison with quantitative coronary angiography (QCA) and CTA consensus reading, and (2) (semi-)automatically segment the coronary lumen on CTA, in comparison with expert's manual annotation. A database consisting of 48 multicenter multivendor cardiac CTA datasets with corresponding reference standards are described and made available. The algorithms from 11 research groups were quantitatively evaluated and compared. The results show that (1) some of the current stenosis detection/quantification algorithms may be used for triage or as a second-reader in clinical practice, and that (2) automatic lumen segmentation is possible with a precision similar to that obtained by experts. The framework is open for new submissions through the website, at http://coronary.bigr.nl/stenoses/.
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H. A. Kirişli, M. Schaap, C. T. Metz, A. S. Dharampal, W. B. Meijboom, et al.. Standardized evaluation framework for evaluating coronary artery stenosis detection, stenosis quantification and lumen segmentation algorithms in computed tomography angiography.. Medical Image Analysis, Elsevier, 2013, 17 (8), pp.859-876. 〈10.1016/j.media.2013.05.007〉. 〈hal-00874107〉

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