Outcome of Poor-Grade Subarachnoid Hemorrhage as Determined by Biomarkers of Glucose Cerebral Metabolism

G.K. Barcelos (1, 2, 3, 4) , Y. Tholance (1, 3) , S. Grousson (5) , B. Renaud (3, 6) , A. Perret-Liaudet (1, 3) , F. Dailler (5) , L. Zimmer (1, 7)

1 CRNL - Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
2 Department of Anesthesiology, Pharmacology and Intensive Care
3 Neurochemistry Unit, Department of Biochemistry, Neurological Hospital,
4 Soins Intensifs, Département APSI
5 Intensive Care Unit, Neurological Hospital
6 NeuroChem Platform
7 CERMEP - imagerie du vivant - Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant

PURPOSE: The aim of this study was to determine if the measurement of blood biomarkers of glucose cerebral metabolism, performed with retrograde jugular catheter, could predict the outcome of poor-grade aneurysmal subarachnoid hemorrhage (aSAH) patients. METHODS: This study was conducted in 68 poor-grade aSAH patients. A total of 4,024 blood samples obtained from jugular and radial catheters were analyzed for glucose, lactate, and oxygen content every 8 h for 10 ± 0.5 days. Metabolic ratio (MR) and lactate-oxygen index (LOI) were obtained by ratios using arterio-jugular differences. Functional outcome was evaluated at 12 months with the Glasgow Outcome Scale. RESULTS: Outcome was unfavorable in 40 patients. In this group of patients, the MR was significantly lower (p < 0.0001) and the LOI was significantly higher (p = 0.0001) than in the group with favorable outcome. The MR cutoff value, below which the patients are likely to have an unfavorable outcome, was determined to be 3.35. More interestingly, the data obtained in this study demonstrated that the patients achieving an unfavorable outcome were distinguished from those with a favorable outcome by having at least three events of MR inferior to 3.35 (sensitivity = 90 %, specificity = 82.1 %). Moreover, in patients who developed cerebral vasospasm, we observed a significant decrease in the MR. CONCLUSION: Our data provide additional support to the view that the MR is a reliable marker for predicting the outcome of poor-grade aSAH patients. Prospective studies are needed to confirm its value in multimodal monitoring.

G.K. Barcelos, Y. Tholance, S. Grousson, B. Renaud, A. Perret-Liaudet, et al.. Outcome of Poor-Grade Subarachnoid Hemorrhage as Determined by Biomarkers of Glucose Cerebral Metabolism. Neurocritical Care, 2013, 18 (2), pp.234-244. ⟨10.1007/s12028-012-9810-1⟩. ⟨hal-00847412⟩