Targeting multiplicity: the key factor for anti-cancer nanoparticles.

M. Gary-Bobo (1) , O. Vaillant (1) , M. Maynadier (1) , I. Basile (1) , A. Gallud (1) , K. El Cheikh (1) , E. Bouffard (1) , A. Morere (1) , X. Rébillard (1) , P. Puche (1) , P. Nirdé (1) , M. Garcia (1)

1 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]

In this mini-review, we focus on different strategies to bring nanotools specifically to cancer cells. We discuss about a better targeting of tumor, combining the characteristics of tumor environment, the increase in nanoparticles life time, the biomarkers overexpressed on cancer cells and different physical methods for non invasive therapies. Here we detail the necessity of a synergy between passive and active targeting for an actual specificity of cancer cells.

Mots clés: non-invasive therapy; Cancer; multiple targeting; nanoparticles

Domaines: Chimie organique

M. Gary-Bobo, O. Vaillant, M. Maynadier, I. Basile, A. Gallud, et al.. Targeting multiplicity: the key factor for anti-cancer nanoparticles.. Current Medicinal Chemistry, 2013, 20 (15), pp.1946-1955. ⟨10.2174/0929867311320150002⟩. ⟨hal-00841552⟩