Trojan horse at cellular level for tumor gene therapies.

Abstract : Among innovative strategies developed for cancer treatments, gene therapies stand of great interest despite their well-known limitations in targeting, delivery, toxicity or stability. The success of any given gene-therapy is highly dependent on the carrier efficiency. New approaches are often revisiting the mythic trojan horse concept to carry therapeutic nucleic acid, i.e. DNAs, RNAs or small interfering RNAs, to pathologic tumor site. Recent investigations are focusing on engineering carrying modalities to overtake the above limitations bringing new promise to cancer patients. This review describes recent advances and perspectives for gene therapies devoted to tumor treatment, taking advantage of available knowledge in biotechnology and medicine.
Document type :
Journal articles
Complete list of metadatas

https://hal.archives-ouvertes.fr/hal-00840161
Contributor : Isabelle Frapart <>
Submitted on : Monday, July 1, 2013 - 4:58:03 PM
Last modification on : Tuesday, April 30, 2019 - 2:24:02 PM

Identifiers

Collections

Citation

Guillaume Collet, Catherine Grillon, Mahdi Nadim, Kieda Claudine. Trojan horse at cellular level for tumor gene therapies.. Gene, Elsevier, 2013, 525 (2), pp.208-216. ⟨10.1016/j.gene.2013.03.057⟩. ⟨hal-00840161⟩

Share

Metrics

Record views

73