Analytical Microsystems for Biomedical and Environmental Applications

Abstract : wo types of analytical microsystems for the detection of species of interest in biomedical diagnosis and in environmental monitoring are specifically described in this paper. We describe a novel device that will measure whole blood concentration of D-dimer, a recognized biomarker of increased blood clotting activity and that will then offer opportunity to use the test in the point of care setting. The device combines innovation in antibody bio-engineering for high specificity immunoassay-based diagnostics and nano/micro engineered impedimetric analysis electrodes incorporating a biocompatible polymer substrate with development of a disposable microfluidic manifold, enabling diagnostics at the point-of-first-contact. The feasibility of a generic microsytem integrating a microfluidic system of concentration and a module of electrochemical detection is demonstrated for the four metals of the European directive (DCE 2000/60/EC) for the quality of water resource: cadmium, mercury, lead and nickel.
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Submitted on : Tuesday, April 9, 2013 - 5:10:42 PM
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  • HAL Id : hal-00809740, version 1

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Nicole Jaffrezic-Renault, Abdelhamid Errachid. Analytical Microsystems for Biomedical and Environmental Applications. Biocybernetics and Biomedical Engineering, 2011, 31 (4), pp.3-16. ⟨hal-00809740⟩

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