Analytical Microsystems for Biomedical and Environmental Applications

Nicole Jaffrezic-Renault (1) , Abdelhamid Errachid (1)

1 SIMS - Surfaces-(bio)Interfaces - Micro & Nano Systèmes (2011-2014)

wo types of analytical microsystems for the detection of species of interest in biomedical diagnosis and in environmental monitoring are specifically described in this paper. We describe a novel device that will measure whole blood concentration of D-dimer, a recognized biomarker of increased blood clotting activity and that will then offer opportunity to use the test in the point of care setting. The device combines innovation in antibody bio-engineering for high specificity immunoassay-based diagnostics and nano/micro engineered impedimetric analysis electrodes incorporating a biocompatible polymer substrate with development of a disposable microfluidic manifold, enabling diagnostics at the point-of-first-contact. The feasibility of a generic microsytem integrating a microfluidic system of concentration and a module of electrochemical detection is demonstrated for the four metals of the European directive (DCE 2000/60/EC) for the quality of water resource: cadmium, mercury, lead and nickel.

Mots clés: analytical microsystems; fluidic microsystems; Electrochemical Impedance Spectroscopy; Deep Venous Thrombosis; water resource; heavy metals; diamond like carbon; DEEP-VEIN THROMBOSIS; IMPEDANCE SPECTROSCOPY; VENOUS THROMBOEMBOLISM; CONDUCTING POLYMERS; PULMONARY-EMBOLISM; CLINICAL-MODEL; IMMOBILIZATION; MANAGEMENT; DIAGNOSIS; FILMS

Domaines: Chimie analytique

Nicole Jaffrezic-Renault, Abdelhamid Errachid. Analytical Microsystems for Biomedical and Environmental Applications. Biocybernetics and Biomedical Engineering, 2011, 31 (4), pp.3-16. ⟨hal-00809740⟩