Relation between brain lesion location and clinical outcome in patients with severe traumatic brain injury: a diffusion tensor imaging study using voxel-based approaches.
Résumé
The early prediction of consciousness recovery from traumatic brain injury (TBI) is crucial to make decisions about the appropriate level of initial care. Diffusion tensor imaging (DTI) has been proposed as biomarker of white matter injury, that could be used in a classification purpose. Instead of region-of-interest-based approach, we applied voxel-based approach on 30 TBI patients to identify, without any prior, the brain regions that were specifically damaged in unfavorable 1-year outcome group compare to the favorable one. DTI were acquired at mean 23 days (5-53 days) and two DTI-derived indices, fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were tested. Our results showed that 1) ADC is not a relevant biomarker for early 1-year outcome prognosis; 2) FA measured in inferior longitudinal fasciculus, in cerebral peduncle, in posterior limb of the internal capsule and in posterior corpus callosum is specifically decreased in unfavorable outcome group compare to the favorable one. 3) a Linear Discriminant Analysis using the FA measured in these four regions showed good classification performance (sensitivity=86% and specificity=86%). These findings confirm the relevance of the use of DTI as biomarkers for consciousness recovery after TBI and support the possible use of these biomarkers for early classification of the patients to adapt the level of initial care.
Origine : Fichiers produits par l'(les) auteur(s)
Loading...