One-step synthesis of 1-halo-1,3-butadienes via ruthenium-catalysed hydrohalogenative dimerisation of alkynes.

Hubert Klein (1) , Thierry Roisnel (1) , Christian Bruneau (1) , Sylvie Dérien (1)

1 ISCR - Institut des Sciences Chimiques de Rennes

An efficient, novel and direct access to 1-halo-1,3-butadienes is developed. This stereoselective ruthenium-catalysed reaction proceeds under mild conditions via the head-to-head oxidative coupling of two alkynes and a concomitant hydrohalogenation.

Domaines: Catalyse

Hubert Klein, Thierry Roisnel, Christian Bruneau, Sylvie Dérien. One-step synthesis of 1-halo-1,3-butadienes via ruthenium-catalysed hydrohalogenative dimerisation of alkynes.. Chemical Communications, 2012, 48 (89), pp.11032-4. ⟨10.1039/c2cc36422k⟩. ⟨hal-00804941⟩