Improved size-tunable preparation of polymeric nanoparticles by microfluidic nanoprecipitation

Florence Bally; Dhiraj Kumar Garg; Christophe A. Serra; Yannick Hoarau; Nicolas Anton; Cyril Brochon; Dambarudhar Parida; Thierry Vandamme; Georges Hadziioannou

doi:10.1016/j.polymer.2012.08.039

Improved size-tunable preparation of polymeric nanoparticles by microfluidic nanoprecipitation

Florence Bally ¹ Dhiraj Kumar Garg ² Christophe A. Serra ^{1, *} Yannick Hoarau ² Nicolas Anton ³ Cyril Brochon ⁴ Dambarudhar Parida ^{1, 4} Thierry Vandamme ^{2, 3} Georges Hadziioannou ^{4, 5}

* Corresponding author

1 Ecole nationale supérieure de chimie, polymères et materiaux de strasbourg (ECPM)

2 IMFS - Institut de Mécanique des Fluides et des Solides

3 Laboratoire de Conception et Application de Molécules Bioactives

4 LCPO - Laboratoire de Chimie des Polymères Organiques

5 TEAM 4 LCPO

Abstract : Size-tunable polymeric nanoparticles have been successfully produced by a microfluidic-assisted nanoprecipitation process. A multilamination micromixer has been chosen to fabricate continuously nanoparticles of methacrylic polymers. Various operating conditions, such as the polymer concentration, the amount of non-solvent and the characteristics of the raw polymer (molecular weight and architecture: linear vs. branched) have been investigated. Their influences on the final particle size, ranging from 76 to 217 nm, have been correlated to the mechanisms leading to the formation of nanoparticles. In this type of microfluidic device, mixing mainly operates by diffusion mass transfer, helped by hydrodynamic focusing. The effect of micromixing on the size of particles has also been shown experimentally and supported by a computational fluid dynamics (CFD) study. A mixing criterion has been defined and numerically calculated to corroborate the effect of the flow rate of polymer solution on the particles size. An increase in the polymer solution flow rate increases the value of this mixing criterion, resulting in smaller nanoparticles.

keyword : Polymeric nanoparticle Nanoprecipitation Microprocess CFD numerical simulation

Document type :

Journal articles

Domain :

Chemical Sciences / Polymers

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https://hal.archives-ouvertes.fr/hal-00803377
Contributor : Dominique Richard <>
Submitted on : Thursday, March 21, 2013 - 5:33:15 PM
Last modification on : Tuesday, March 19, 2019 - 4:08:15 PM

Improved size-tunable preparation of polymeric nanoparticles by microfluidic nanoprecipitation

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Improved size-tunable preparation of polymeric nanoparticles by microfluidic nanoprecipitation

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