Improved size-tunable preparation of polymeric nanoparticles by microfluidic nanoprecipitation

Florence Bally 1 Dhiraj Kumar Garg 2 Christophe A. Serra 1, * Yannick Hoarau 2 Nicolas Anton 3 Cyril Brochon 4 Dambarudhar Parida 1, 4 Thierry Vandamme 2, 3 Georges Hadziioannou 4, 5
* Auteur correspondant
1 Univ Strasbourg - Ecole Europ Chim Polym & Mat, Lab Ing
2 IMFS - Institut de Mécanique des Fluides et des Solides
3 Laboratoire de Conception et Application de Molécules Bioactives
4 LCPO - Laboratoire de Chimie des Polymères Organiques
5 TEAM 4 LCPO
Abstract : Size-tunable polymeric nanoparticles have been successfully produced by a microfluidic-assisted nanoprecipitation process. A multilamination micromixer has been chosen to fabricate continuously nanoparticles of methacrylic polymers. Various operating conditions, such as the polymer concentration, the amount of non-solvent and the characteristics of the raw polymer (molecular weight and architecture: linear vs. branched) have been investigated. Their influences on the final particle size, ranging from 76 to 217 nm, have been correlated to the mechanisms leading to the formation of nanoparticles. In this type of microfluidic device, mixing mainly operates by diffusion mass transfer, helped by hydrodynamic focusing. The effect of micromixing on the size of particles has also been shown experimentally and supported by a computational fluid dynamics (CFD) study. A mixing criterion has been defined and numerically calculated to corroborate the effect of the flow rate of polymer solution on the particles size. An increase in the polymer solution flow rate increases the value of this mixing criterion, resulting in smaller nanoparticles.
keyword : Polymeric nanoparticle Nanoprecipitation Microprocess CFD numerical simulation
Type de document :
Article dans une revue
Polymer, Elsevier, 2012, 53 (22), pp.5045-5051. 〈10.1016/j.polymer.2012.08.039〉
Domaine :
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https://hal.archives-ouvertes.fr/hal-00803377
Contributeur : Dominique Richard <>
Soumis le : jeudi 21 mars 2013 - 17:33:15
Dernière modification le : jeudi 11 janvier 2018 - 06:28:10

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Florence Bally, Dhiraj Kumar Garg, Christophe A. Serra, Yannick Hoarau, Nicolas Anton, et al.. Improved size-tunable preparation of polymeric nanoparticles by microfluidic nanoprecipitation. Polymer, Elsevier, 2012, 53 (22), pp.5045-5051. 〈10.1016/j.polymer.2012.08.039〉. 〈hal-00803377〉

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