Asymmetric synthesis of trifluoromethyl-piperidine based ?-aminoacids and of trifluoromethyl-indolizidines.
Résumé
The asymmetric synthesis of trifluoromethyl-piperidine-based g-aminoacids and of indolizidines bearing a trifluoromethyl group is reported. These rarely described compounds are prepared in a highly enantio-enriched form employing as key step an intramolecular Mannich type process, involving an enantiopure Tfm-aminoketal and ethyl oxobutenoate as aldehyde partner. Used strategy together with obtained compounds allows the access to a wide range of Tfm-N-(poly)heterocycles, structures of obvious interest for the research of new bioactive drugs.