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Assembly of the auditory circuitry by a hox genetic network in the mouse brainstem.

Abstract : Rhombomeres (r) contribute to brainstem auditory nuclei during development. Hox genes are determinants of rhombomere-derived fate and neuronal connectivity. Little is known about the contribution of individual rhombomeres and their associated Hox codes to auditory sensorimotor circuitry. Here, we show that r4 contributes to functionally linked sensory and motor components, including the ventral nucleus of lateral lemniscus, posterior ventral cochlear nuclei (VCN), and motor olivocochlear neurons. Assembly of the r4-derived auditory components is involved in sound perception and depends on regulatory interactions between Hoxb1 and Hoxb2. Indeed, in Hoxb1 and Hoxb2 mutant mice the transmission of low-level auditory stimuli is lost, resulting in hearing impairments. On the other hand, Hoxa2 regulates the Rig1 axon guidance receptor and controls contralateral projections from the anterior VCN to the medial nucleus of the trapezoid body, a circuit involved in sound localization. Thus, individual rhombomeres and their associated Hox codes control the assembly of distinct functionally segregated sub-circuits in the developing auditory brainstem.
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https://hal.archives-ouvertes.fr/hal-00789345
Contributor : Caroline Ruiz <>
Submitted on : Monday, February 18, 2013 - 9:45:35 AM
Last modification on : Tuesday, May 26, 2020 - 6:50:46 PM

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Maria Di Bonito, Yuichi Narita, Bice Avallone, Luigi Sequino, Marta Mancuso, et al.. Assembly of the auditory circuitry by a hox genetic network in the mouse brainstem.. PLoS Genetics, Public Library of Science, 2013, 9 (2), pp.e1003249. ⟨10.1371/journal.pgen.1003249⟩. ⟨hal-00789345⟩

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