Mechanosynthesis of amides in the total absence of organic solvent from reaction to product recovery

Thomas-Xavier Metro (1) , Julien Bonnamour (1) , Thomas Reidon (1) , Jordi Sarpoulet (1) , Jean Martinez (1) , Frédéric Lamaty (1)

1 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]

The synthesis of various amides has been realised avoiding the use of any organic solvent from activation of carboxylic acids with CDI to isolation of the amides. Mechanochemistry was the key point of the process allowing rapid formation of the amide bond and efficient water-based purification of the final products.

Domaines: Chimie organique

Thomas-Xavier Metro, Julien Bonnamour, Thomas Reidon, Jordi Sarpoulet, Jean Martinez, et al.. Mechanosynthesis of amides in the total absence of organic solvent from reaction to product recovery. Chemical Communications, 2012, 48 (96), pp.11781-11783. ⟨10.1039/c2cc36352f⟩. ⟨hal-00784652⟩