Poly(ethylene glycol) as reaction medium for mild Mizoroki-Heck reaction in a ball-mill

Valérie Declerck (1) , Evelina Colacino (1) , Xavier Bantreil (1) , Jean Martinez (1) , Frédéric Lamaty (1)

1 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]

Phosphine-free palladium-catalyzed Mizoroki-Heck reaction was performed using ball-milling in polyethylene glycol under mild conditions. Good to excellent yields of coupling products were obtained. This activation technique also allowed the concomitant formation of round shaped Pd-PEG nanoparticles that were characterized by TEM analysis.

Domains: Organic chemistry; Catalysis

Valérie Declerck, Evelina Colacino, Xavier Bantreil, Jean Martinez, Frédéric Lamaty. Poly(ethylene glycol) as reaction medium for mild Mizoroki-Heck reaction in a ball-mill. Chemical Communications, 2012, 48 (96), pp.11778-11780. ⟨10.1039/c2cc36286d⟩. ⟨hal-00784597⟩