Numerical simulation of the dynamics of molecular markers involved in cell polarisation

Abstract : A cell is polarised when it has developed a main axis of organisation through the reorganisation of its cytosqueleton and its intracellular organelles. Polarisation can occur spontaneously or be triggered by external signals, like gradients of signaling molecules ... In this work, we study mathematical models for cell polarisation. These models are based on nonlinear convection-diffusion equations. The nonlinearity in the transport term expresses the positive loop between the level of protein concentration localised in a small area of the cell membrane and the number of new proteins that will be convected to the same area. We perform numerical simulations and we illustrate that these models are rich enough to describe the apparition of a polarisome.
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Pré-publication, Document de travail
MAP5 2013-01. 15 pages. 2012
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https://hal.archives-ouvertes.fr/hal-00777040
Contributeur : Nicolas Muller <>
Soumis le : mercredi 16 janvier 2013 - 16:43:41
Dernière modification le : lundi 27 mars 2017 - 14:02:54
Document(s) archivé(s) le : samedi 1 avril 2017 - 06:22:22

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  • HAL Id : hal-00777040, version 1
  • ARXIV : 1301.3807

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Vincent Calvez, Nicolas Meunier, Nicolas Muller, Raphael Voituriez. Numerical simulation of the dynamics of molecular markers involved in cell polarisation. MAP5 2013-01. 15 pages. 2012. <hal-00777040>

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