Numerical simulation of the dynamics of molecular markers involved in cell polarisation

Abstract : A cell is polarised when it has developed a main axis of organisation through the reorganisation of its cytosqueleton and its intracellular organelles. Polarisation can occur spontaneously or be triggered by external signals, like gradients of signaling molecules ... In this work, we study mathematical models for cell polarisation. These models are based on nonlinear convection-diffusion equations. The nonlinearity in the transport term expresses the positive loop between the level of protein concentration localised in a small area of the cell membrane and the number of new proteins that will be convected to the same area. We perform numerical simulations and we illustrate that these models are rich enough to describe the apparition of a polarisome.
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https://hal.archives-ouvertes.fr/hal-00777040
Contributor : Nicolas Muller <>
Submitted on : Wednesday, January 16, 2013 - 4:43:41 PM
Last modification on : Tuesday, November 19, 2019 - 11:33:55 AM
Long-term archiving on: Saturday, April 1, 2017 - 6:22:22 AM

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  • HAL Id : hal-00777040, version 1
  • ARXIV : 1301.3807

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Vincent Calvez, Nicolas Meunier, Nicolas Muller, Raphael Voituriez. Numerical simulation of the dynamics of molecular markers involved in cell polarisation. 2012. ⟨hal-00777040⟩

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