Die physiologische Funktion der GABAA Autorezeptoren im Kleinhirn

Joël Chavas (1)

1 LPC - UMR 8118 - Laboratoire de physiologie cérébrale

The physiological effect of GABAA autoreceptors in the cerebellum. In this Diplomarbeit, I measured the reversal potential of GABAA receptors (-56 mV) in the interneurons of the rat cerebellum, using gramicidin perforated patch, . I then determined that the GABAA autoreceptors can be excitatory. Last, I proved that a tonic activation of the GABAA receptors increases the intracellular calcium concentration. To obtain this last result, I performed cell-attached experiments. I used the opening probablity of the BK channels as a probe of the intracellular calcium concentration,.

Domaines: Neurobiologie; Neurosciences

Joël Chavas. Die physiologische Funktion der GABAA Autorezeptoren im Kleinhirn. 1999. ⟨hal-00770779⟩