Biologically Active Polymersomes from Amphiphilic Glycopeptides

Abstract : Polypeptide block copolymers with different block length ratios were obtained by sequential ring-opening polymerization of benzyl-L-glutamate and propargylglycine (PG) N-carboxyanhydrides. Glycosylation of the poly(PG) block was obtained by Huisgens cycloaddition "click" reaction using azide-functionalized galactose. All copolymers were self-assembled using the nanoprecipitation method to obtain spherical and wormlike micelles as well as polymersomes depending on the block length ratio and the nanoprecipitation conditions. These structures display bioactive galactose units in the polymersome shell, as proven by selective lectin binding experiments.
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https://hal.archives-ouvertes.fr/hal-00757517
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Submitted on : Tuesday, November 27, 2012 - 10:43:47 AM
Last modification on : Thursday, January 11, 2018 - 6:28:10 AM

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Jin Huang, Colin Bonduelle, Julie Thevenot, Sébastien Lecommandoux, Andreas Heise. Biologically Active Polymersomes from Amphiphilic Glycopeptides. Journal of the American Chemical Society, American Chemical Society, 2012, 134 (1), pp.119-122. ⟨10.1021/ja209676p⟩. ⟨hal-00757517⟩

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