Insulated gold micro singularities for high density cell trapping based on dielectrophoresis

Abstract : Dielectrophoresis (DEP) is broadly used in microfluidic systems for the cell therapies or medical diagnostics [1] because of its capability to handle and sort biological cells [2,3]. In this paper, a new method to trap cells on-chip with high density arraying capabilities is proposed. The principle is based on the use of metallic singularities arrayed within the flowing channel of the biochip. These singularities, even at a floating potential, induce a non uniform electrical field within the structure, responsible of a strong DEP force applied to cells. Indeed, we will demonstrate in the paper that metallic singularities generate stronger DEP forces, compared to more conventional methods where micro-dots of insulating material are arrayed to produce the electrical field traps. [4]. To the best of our knowledge, we report here the first successful use of such floating potential metallic singularities to trap cells
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Claire Dalmay, Olivier Français, Frédéric Subra, Bruno Le Pioufle. Insulated gold micro singularities for high density cell trapping based on dielectrophoresis. Nanobiotech, 2011, Montreux, Switzerland. ⟨hal-00739186⟩

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