Tumor growth modeling based on cell and tumor lifespans

Roukaya Keinj 1 Thierry Bastogne 2, 3, * Pierre Vallois 3, 4
* Corresponding author
1 MOISE - Modelling, Observations, Identification for Environmental Sciences
Inria Grenoble - Rhône-Alpes, LJK - Laboratoire Jean Kuntzmann, INPG - Institut National Polytechnique de Grenoble
3 BIGS - Biology, genetics and statistics
Inria Nancy - Grand Est, IECL - Institut Élie Cartan de Lorraine
Abstract : This paper deals with the lifespan modeling of heterogenous tumors treated by radiotherapy. A bi-scale model describing the cell and tumor lifespans by random variables is proposed. First and second-order moments, as well as the cumulative distribution functions and confidence intervals are expressed for the two lifespans with respect to the model parameters. One interesting result is that the mean value of the tumor lifespan can be approached by a logarithmic function of the initial cancer cell number. Moreover, we show that TCP and NTCP, used in radiotherapy to evaluate, optimize and compare treatment plans, can be derived from the tumor lifespan and the surrounding healthy tissue respectively. Finally, we propose a ROC curve, entitled ECT (Efficiency-Complication Trade-off), suited to the selection by clinicians of the appropriate treatment planning.
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Roukaya Keinj, Thierry Bastogne, Pierre Vallois. Tumor growth modeling based on cell and tumor lifespans. Journal of Theoretical Biology, Elsevier, 2012, 312, pp.76-86. ⟨10.1016/j.jtbi.2012.07.008⟩. ⟨hal-00730315⟩

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