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Article Dans Une Revue Journal of Biomedical Optics Année : 2012

Microscopic structural study of collagen aging in isolated fibrils using polarized second harmonic generation

Résumé

Polarization resolved second harmonic generation (PSHG) is developed to study, at the microscopic scale, the impact of aging on the structure of type I collagen fibrils in two-dimensional coatings. A ribose-glycated collagen is also used to mimic tissue glycation usually described as an indicator of aging. PSHG images are analyzed using a generic approach of the molecular disorder information in collagen fibrils, revealing significant changes upon aging, with a direct correlation between molecular disorder and fibril diameters.
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Dates et versions

hal-00729062 , version 1 (07-09-2012)

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Dora Aït-Belkacem, Marie Guilbert, Julien Duboisset, Patrick Ferrand, Muriel Roche, et al.. Microscopic structural study of collagen aging in isolated fibrils using polarized second harmonic generation. Journal of Biomedical Optics, 2012, 17 (8), pp.080506. ⟨10.1117/1.JBO.17.8.080506⟩. ⟨hal-00729062⟩
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