Functionalized single-walled carbon nanotubes containing traces of iron as new negative MRI contrast agents for in vivo imaging.

Abstract : Single-walled carbon nanotubes (SWCNTs) containing traces of iron oxide were functionalized by noncovalent lipid-PEG or covalent carboxylic acid function to supply new efficient MRI contrast agents for in vitro and in vivo applications. Longitudinal (r(1)) and transversal (r(2)) water proton relaxivities were measured at 300 MHz, showing a stronger T(2) feature as an MRI contrast agent (r(2)/r(1) = 190 for CO(2) H functionalisation). The r(2) relaxivity was demonstrated to be correlated to the presence of iron oxide in the SWNT-carboxylic function COOH, in comparison to iron-free ones. Biodistribution studies on mice after a systemic injection showed a negative MRI contrast in liver, suggesting the presence of the nanotubes in this organ until 48 h after i.v. injection. The presence of carbon nanotubes in liver was confirmed after ex vivo carbon extraction. Finally, cytotoxicity studies showed no apparent effect owing to the presence of the carbon nanotubes. The functionalized carbon nanotubes were well tolerated by the animals at the dose of 10 µg g(-1) body weight.
Document type :
Journal articles
Complete list of metadatas

https://hal.archives-ouvertes.fr/hal-00721846
Contributor : Isabelle Frapart <>
Submitted on : Monday, July 30, 2012 - 4:25:51 PM
Last modification on : Thursday, April 11, 2019 - 4:02:22 PM

Links full text

Identifiers

Citation

Bich-Thuy Doan, Johanne Seguin, Marie Breton, Ronan Le Beherec, Michel Bessodes, et al.. Functionalized single-walled carbon nanotubes containing traces of iron as new negative MRI contrast agents for in vivo imaging.. Contrast Media and Molecular Imaging, Wiley, 2012, 7 (2), pp.153-159. ⟨10.1002/cmmi.474⟩. ⟨hal-00721846⟩

Share

Metrics

Record views

219