Modular Construction of Fluorescent Lipophosphoramidates by Click Chemistry

Abstract : The synthesis of fluorescent lipophosphoramidates is reported. Their modular construction allows several variations of the molecular structure including the separation of the fluorescent probe from the lipophosphoramidate moiety by a short methylene or by a tetraethylene glycol spacer. The last step of the convergent synthesis is a Huisgen click reaction, which assembles the fluorescent probe with the lipophosphoramidate part. Five fluorescent probes have been considered in this study including coumarin, NBD, fluorescein, naphthalimide and cyanine.
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Mathieu Berchel, Jean-Piere Haelters, Hélène Couthon, Laure Deschamps, Patrick Midoux, et al.. Modular Construction of Fluorescent Lipophosphoramidates by Click Chemistry. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2011, pp.6294-6303. ⟨10.1002/ejoc.201100900⟩. ⟨hal-00720537⟩



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