Degree of Chemical Functionalization of Carbon Nanotubes Determines Tissue Distribution and Excretion Profile.

Khuloud T Al-Jamal (1) , Antonio Nunes (1) , Laura Methven (1) , Hanene Ali-Boucetta (1) , Shouping Li (2) , Francesca M Toma (3) , M Antonia Herrero (3) , Wafa' T Al-Jamal (1) , Huub M M ten Eikelder (4) , Julie Foster (5) , Stephen Mather (5) , Maurizio Prato (3) , Alberto Bianco (2) , Kostas Kostarelos (1)

1 Nanomedicine Laboratory
2 ICT - Immunologie et chimie thérapeutiques
3 Dipartimento di Scienze Farmaceutiche
4 Biomodeling and Bioinformatics Group
5 Department of Nuclear Medicine

Getting rid of the tubes: An assessment of the retention of functionalized multi-walled carbon nanotubes (MWNTs) in the organs of mice was carried out using single photon emission computed tomography and quantitative scintigraphy. Increasing the degree of functionalization on MWNTs enhanced renal clearance, while lower functionalization promoted reticuloendethelial system accumulation.

Domaines: Chimie thérapeutique

Khuloud T Al-Jamal, Antonio Nunes, Laura Methven, Hanene Ali-Boucetta, Shouping Li, et al.. Degree of Chemical Functionalization of Carbon Nanotubes Determines Tissue Distribution and Excretion Profile.. Angewandte Chemie International Edition, 2012, 51, pp.6389-6393. ⟨10.1002/anie.201201991⟩. ⟨hal-00701468⟩