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The pro-Th2 cytokine IL-33 directly interacts with invariant NKT and NK cells to induce IFN-gamma production.

Abstract : IL-33 has recently been identified as a cytokine endowed with pro-Th2 functions, raising the question of its effect on invariant natural killer T cell (iNKT), which are potent IL-4 producers. Here, we report a two-fold increase of iNKT-cell counts in spleen and liver after a 7-day treatment of mice with IL-33, which results from a direct effect, given that purified iNKT cells express the T1/ST2 receptor constitutively and respond to IL-33 by in vitro expansion and functional activation. Conversely to the expected pro-Th2 effect, IL-33 induced a preferential increase in IFN-gamma rather than IL-4 production upon TCR engagement that depended on endogenous IL-12. Moreover, in combination with the pro-inflammatory cytokine IL-12, IL-33 enhanced IFN-gamma production by both iNKT and NK cells. Taken together these data support the conclusion that IL-33 can contribute as a co-stimulatory factor to innate cellular immune responses.
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https://hal.archives-ouvertes.fr/hal-00676402
Contributor : Alice Brébion <>
Submitted on : Monday, March 5, 2012 - 11:46:36 AM
Last modification on : Thursday, January 14, 2021 - 11:27:06 AM

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Elvire Bourgeois, Linh Pham Van, Michel Samson, Séverine Diem, Anne Barra, et al.. The pro-Th2 cytokine IL-33 directly interacts with invariant NKT and NK cells to induce IFN-gamma production.. European Journal of Immunology, Wiley-VCH Verlag, 2009, 39 (4), pp.1046-55. ⟨10.1002/eji.200838575⟩. ⟨hal-00676402⟩

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