Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses.

Botond Z Igyártó (1) , Krystal Haley (1) , Daniela Ortner (1) , Aleh Bobr (1) , Maryam Gerami-Nejad (2) , Brian T Edelson (3) , Sandra M Zurawski (4) , Bernard Malissen (5) , Gerard Zurawski (4) , Judith Berman (2) , Daniel H Kaplan (1)

1 Center for Immunology - University of Minnesota
2 Department of Molecular & Cellular Biology - University of Minnesota
3 Washington University School of Medecine - Department of Pathology & Immunology
4 BIIR - Baylor Institute for Immunology Research
5 CIML - Centre d'Immunologie de Marseille - Luminy

Skin-resident dendritic cells (DCs) are well positioned to encounter cutaneous pathogens and are required for the initiation of adaptive immune responses. There are at least three subsets of skin DC- Langerhans cells (LC), Langerin(+) dermal DCs (dDCs), and classic dDCs. Whether these subsets have distinct or redundant function in vivo is poorly understood. Using a Candida albicans skin infection model, we have shown that direct presentation of antigen by LC is necessary and sufficient for the generation of antigen-specific T helper-17 (Th17) cells but not for the generation of cytotoxic lymphocytes (CTLs). In contrast, Langerin(+) dDCs are required for the generation of antigen specific CTL and Th1 cells. Langerin(+) dDCs also inhibited the ability of LCs and classic DCs to promote Th17 cell responses. This work demonstrates that skin-resident DC subsets promote distinct and opposing antigen-specific responses.

Domaines: Immunologie

Botond Z Igyártó, Krystal Haley, Daniela Ortner, Aleh Bobr, Maryam Gerami-Nejad, et al.. Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses.. Immunity, 2011, 35 (2), pp.260-72. ⟨10.1016/j.immuni.2011.06.005⟩. ⟨hal-00667766⟩