Icosahedral viruses: physical principles of capsid structure classification, self-assembly and maturation

Abstract : In the present work we generalize Landau theory of crystallization to explain and to classify the capsid structures of small viruses with spherical topology and icosahedral symmetry. We develop an explicit method which predicts the positions of centers of mass for the proteins constituting viral capsid shell. The peculiarities of the assembly thermodynamics are also discussed. Finally, we show the relation between the protein density distributions obtained and the infectivity properties of several human viruses.
Type de document :
Communication dans un congrès
Physics and Mechanics of Biological Systems, Dec 2010, Paris, France. 2010


https://hal.archives-ouvertes.fr/hal-00654104
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Soumis le : mardi 20 décembre 2011 - 19:00:03
Dernière modification le : mardi 8 décembre 2015 - 01:02:41

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  • HAL Id : hal-00654104, version 1

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Vladimir Lorman. Icosahedral viruses: physical principles of capsid structure classification, self-assembly and maturation. Physics and Mechanics of Biological Systems, Dec 2010, Paris, France. 2010. <hal-00654104>

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